Meprobamate Reaction

Meprobamate in tetanus.

T H E value of oral meprobamate (syn. Equanil, Miltown, Mepavlon) has been for some months 1st day after admission. In the morning his breathing was rather laboured and mucus collected in his throat. Later he managed investigated in this hospital group, as a compoto swallow this and his breathing improved. He was nent of the premedication for children. An interesting publication has appeared re...

Reversible agranulocytosis due to meprobamate.

A 52 year old man admitted to hospital in a toxic state, was found to have agranulocytosis, which recovered when an analgesic containing meprobamate was stopped. The patient was known to have had similar symptoms 9 months previously when the drug was first used, thereby demonstrating an idiosyncratic reaction to meprobamate.

[Acute meprobamate poisoning. Clinical and medicolegal aspects].

Severe meprobamate poisoning: successful treatment with haemoperfusion.

Charcoal haemoperfusion used to treat a 56-year-old woman who had taken a very large overdose of meprobamate was followed by fully recovery. The plasma clearance of meprobamate was 153 ml/min and this compares favourably with values obtained for haemodialysis. The indications for haemoperfusion are reviewed.

Determination of carisoprodol and meprobamate in oral fluid.

The determination of carisoprodol and its metabolite meprobamate in oral fluid using solid-phase extraction and liquid chromatography with tandem mass spectral detection (LC-MS-MS) and its application to authentic specimens is described. The method employs collection of oral fluid with the Quantisal device, extraction using cation exchange/hydrophobic solid-phase columns, and LC-MS-MS in positi...